Ontology highlight
ABSTRACT:
SUBMITTER: Graybill C
PROVIDER: S-EPMC4372073 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Graybill Chiharu C Prehoda Kenneth E KE
Biochemistry 20140716 30
In Par complex-mediated cell polarity, phosphorylation by atypical protein kinase C (aPKC) is coupled to substrate cortical displacement. Polarized substrates often contain multiple phosphorylation sites, but the role of multisite phosphorylation in Par-mediated polarity remains unclear. Here, we have dissected the role of the three aPKC phosphorylation sites within the tumor suppressor Lethal giant larvae. Using a cultured Drosophila S2 cell cortical displacement assay, we observed that phospho ...[more]