Ontology highlight
ABSTRACT:
SUBMITTER: Stavrinides A
PROVIDER: S-EPMC4372254 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Stavrinides Anna A Tatsis Evangelos C EC Foureau Emilien E Caputi Lorenzo L Kellner Franziska F Courdavault Vincent V O'Connor Sarah E SE
Chemistry & biology 20150312 3
The extraordinary chemical diversity of the plant-derived monoterpene indole alkaloids, which include vinblastine, quinine, and strychnine, originates from a single biosynthetic intermediate, strictosidine aglycone. Here we report for the first time the cloning of a biosynthetic gene and characterization of the corresponding enzyme that acts at this crucial branchpoint. This enzyme, an alcohol dehydrogenase homolog, converts strictosidine aglycone to the heteroyohimbine-type alkaloid tetrahydroa ...[more]