Ontology highlight
ABSTRACT:
SUBMITTER: Parnell E
PROVIDER: S-EPMC4372255 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Parnell Euan E Smith Brian O BO Yarwood Stephen J SJ
Cellular signalling 20150212 5
We have identified a conserved nuclear pore localisation signal (NPLS; amino acids 764-838 of EPAC1) in the catalytic domains of the cAMP-sensors, EPAC1 and EPAC2A. Consequently, EPAC1 is mainly localised to the nuclear pore complex in HEK293T cells where it becomes activated following stimulation with cAMP. In contrast, structural models indicate that the cAMP-binding domain of EPAC2A (CNBD1) blocks access to the conserved NPLS in EPAC2A, reducing its ability to interact with nuclear binding si ...[more]