Ontology highlight
ABSTRACT:
SUBMITTER: Spooner CJ
PROVIDER: S-EPMC4373467 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Spooner Chauncey J CJ Cheng Jason X JX Pujadas Elisabet E Laslo Peter P Singh Harinder H
Immunity 20091008 4
The transcription factor PU.1, encoded by the Sfpi1 gene, functions in a graded manner to regulate macrophage versus B cell generation; its higher concentration favors the macrophage fate. We demonstrated that Gfi1 reciprocally promoted B cell fate choice at the expense of myeloid progeny. Gfi1(-/-) multipotential progenitors (MPPs) were unable to constrain the expression of PU.1 because Gfi1 functioned to repress the Sfpi1 gene by displacing PU.1 from positive autoregulatory elements. Attenuati ...[more]