Ontology highlight
ABSTRACT:
SUBMITTER: Rothchild AC
PROVIDER: S-EPMC5068277 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Rothchild Alissa C AC Sissons James R JR Shafiani Shahin S Plaisier Christopher C Min Deborah D Mai Dat D Gilchrist Mark M Peschon Jacques J Larson Ryan P RP Bergthaler Andreas A Baliga Nitin S NS Urdahl Kevin B KB Aderem Alan A
Proceedings of the National Academy of Sciences of the United States of America 20160928 41
The regulation of host-pathogen interactions during Mycobacterium tuberculosis (Mtb) infection remains unresolved. MicroRNAs (miRNAs) are important regulators of the immune system, and so we used a systems biology approach to construct an miRNA regulatory network activated in macrophages during Mtb infection. Our network comprises 77 putative miRNAs that are associated with temporal gene expression signatures in macrophages early after Mtb infection. In this study, we demonstrate a dual role for ...[more]