Dataset Information
Ligand-controlled regiodivergent palladium-catalyzed decarboxylative allylation reaction to access ?,?-difluoroketones.
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ABSTRACT:
SUBMITTER: Yang MH
PROVIDER: S-EPMC4373536 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Ligand-controlled regiodivergent palladium-catalyzed decarboxylative allylation reaction to access α,α-difluoroketones.
Angewandte Chemie (International ed. in English) 20150107 8
α,α-Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. To access the α-allyl-α,α-difluoroketone substructure, complementary palladium-catalyzed decarboxylative allylation reactions were developed to provide linear and branched α-allyl-α,α-difluoroketones. For these orthogonal processes, the fluorination pattern of the substrate enabled the ligands to dictate the regioselectivity of the transformations. ...[more]