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2-Aminopyridines via reaction of pyridine N-oxides and activated isocyanides.

ABSTRACT: A practical and efficient method for the synthesis of substituted 2-aminopyridines from pyridine N-oxides is reported. Yields of purified, isolated products of up to 84% are observed for the one-pot, two-step process. The reaction involves an in situ deprotection of an isolable N-formylaminopyridine intermediate and facilitates the synthesis of 2-aminopyridines for which other methods fail.

SUBMITTER: Vamos M

PROVIDER: S-EPMC4374735 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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2-Aminopyridines via reaction of pyridine N-oxides and activated isocyanides.

Vamos Mitchell M Cosford Nicholas D P ND

The Journal of organic chemistry 20140218 5

A practical and efficient method for the synthesis of substituted 2-aminopyridines from pyridine N-oxides is reported. Yields of purified, isolated products of up to 84% are observed for the one-pot, two-step process. The reaction involves an in situ deprotection of an isolable N-formylaminopyridine intermediate and facilitates the synthesis of 2-aminopyridines for which other methods fail. ...[more]

PMID: 24490824

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