Dataset Information

Sarcopenia-related parameters and incident disability in older persons: results from the "invecchiare in Chianti" study.

ABSTRACT: Current operational definitions of sarcopenia are based on algorithms' simultaneous considering measures of skeletal muscle mass and muscle-specific as well as global function. We hypothesize that quantitative and qualitative sarcopenia-related parameters may not be equally predictive of incident disability, thus presenting different clinical relevance.Data are from 922 elder adults (mean age = 73.9 years) with no activities of daily living (ADL) impairment recruited in the "Invecchiare in Chianti" study. Incident disability in ?1 ADL defined the outcome of interest. The specific capacities of following sarcopenia-related parameters at predicting incident ADL disability were compared: residuals of skeletal muscle mass, fat-adjusted residuals of skeletal muscle mass, muscle density, ankle extension strength, ratio ankle extension strength/muscle mass, gait speed, and handgrip strength.During the follow-up (median = 9.1 years), 188 (20.4%) incident ADL disability events were reported. Adjusted models showed that only gait speed was significantly associated with the outcome in both men (per standard deviation [SD] = 0.23 m/s increase, hazard ratio [HR] = 0.46, 95% confidence interval [CI] = 0.33-0.63; p < .001) and women (per SD = 0.24 m/s increase, HR = 0.64, 95% CI = 0.50-0.82; p < .001). In women, the fat-adjusted lean mass residual (per SD = 4.41 increase, HR = 0.79, 95% CI = 0.65-0.96; p = .02) and muscle density (per SD = 3.60 increase, HR = 0.76, 95% CI = 0.61-0.93; p = .01) were the only other parameters that predicted disability. In men, several of the tested variables (except muscle mass measures) reported significant results.Gender strongly influences which sarcopenia-related parameters predict disability. Gait speed was a powerful predictor of disability in both men and women, but its nonmuscle-specific nature should impose caution about its inclusion in definitions of sarcopenia.

SUBMITTER: Cesari M

PROVIDER: S-EPMC4375415 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Sarcopenia-related parameters and incident disability in older persons: results from the "invecchiare in Chianti" study.

Cesari Matteo M Rolland Yves Y Abellan Van Kan Gabor G Bandinelli Stefania S Vellas Bruno B Ferrucci Luigi L

The journals of gerontology. Series A, Biological sciences and medical sciences 20141015 4

<h4>Background</h4>Current operational definitions of sarcopenia are based on algorithms' simultaneous considering measures of skeletal muscle mass and muscle-specific as well as global function. We hypothesize that quantitative and qualitative sarcopenia-related parameters may not be equally predictive of incident disability, thus presenting different clinical relevance.<h4>Methods</h4>Data are from 922 elder adults (mean age = 73.9 years) with no activities of daily living (ADL) impairment rec ...[more]

PMID: 25320055

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Dataset Information

Sarcopenia-related parameters and incident disability in older persons: results from the "invecchiare in Chianti" study.

Publications

Sarcopenia-related parameters and incident disability in older persons: results from the "invecchiare in Chianti" study.

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