Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury.
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ABSTRACT:
SUBMITTER: Schaub JR
PROVIDER: S-EPMC4376310 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
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Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury.
Schaub Johanna R JR Malato Yann Y Gormond Coralie C Willenbring Holger H
Cell reports 20140814 4
Hepatocytes provide most liver functions, but they can also proliferate and regenerate the liver after injury. However, under some liver injury conditions, particularly chronic liver injury where hepatocyte proliferation is impaired, liver stem cells (LSCs) are thought to replenish lost hepatocytes. Conflicting results have been reported about the identity of LSCs and their contribution to liver regeneration. To address this uncertainty, we followed candidate LSC populations by genetic fate trac ...[more]
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