Ontology highlight
ABSTRACT:
SUBMITTER: Rebsamen M
PROVIDER: S-EPMC4376665 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Rebsamen Manuele M Pochini Lorena L Stasyk Taras T de Araújo Mariana E G ME Galluccio Michele M Kandasamy Richard K RK Snijder Berend B Fauster Astrid A Rudashevskaya Elena L EL Bruckner Manuela M Scorzoni Stefania S Filipek Przemyslaw A PA Huber Kilian V M KV Bigenzahn Johannes W JW Heinz Leonhard X LX Kraft Claudine C Bennett Keiryn L KL Indiveri Cesare C Huber Lukas A LA Superti-Furga Giulio G
Nature 20150107 7544
Cell growth and proliferation are tightly linked to nutrient availability. The mechanistic target of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels, glucose and amino acids to modulate metabolic status and cellular responses. mTORC1 is activated at the surface of lysosomes by the RAG GTPases and the Ragulator complex through a not fully understood mechanism monitoring amino acid availability in the lysosomal lumen and involving the vacuolar H(+)-ATPase. Her ...[more]