Ontology highlight
ABSTRACT:
SUBMITTER: Bao K
PROVIDER: S-EPMC4377729 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Bao Kai K Nasr Khaled A KA Hyun Hoon H Lee Jeong Heon JH Gravier Julien J Gibbs Summer L SL Choi Hak Soo HS
Theranostics 20150301 6
Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we describe the development of a series of PAM-conjugated NIR fluorophores that varied in net charges and hydrophobicity, and compared their bone targeting efficiency, biodistribution, ...[more]