Unknown

Dataset Information

0

Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging.


ABSTRACT: Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we describe the development of a series of PAM-conjugated NIR fluorophores that varied in net charges and hydrophobicity, and compared their bone targeting efficiency, biodistribution, and blood clearance. Since the targeting moiety, PAM, is highly negatively charged but small, the overall in vivo bone targeting and biodistribution were mediated by the physicochemical properties of conjugated fluorophores.

SUBMITTER: Bao K 

PROVIDER: S-EPMC4377729 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

altmetric image

Publications

Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging.

Bao Kai K   Nasr Khaled A KA   Hyun Hoon H   Lee Jeong Heon JH   Gravier Julien J   Gibbs Summer L SL   Choi Hak Soo HS  

Theranostics 20150301 6


Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we describe the development of a series of PAM-conjugated NIR fluorophores that varied in net charges and hydrophobicity, and compared their bone targeting efficiency, biodistribution,  ...[more]

Similar Datasets

| S-EPMC4982771 | biostudies-literature
| S-EPMC7713230 | biostudies-literature
| S-EPMC8179124 | biostudies-literature
| S-EPMC4221277 | biostudies-literature
| S-EPMC6401027 | biostudies-literature
| S-EPMC9424606 | biostudies-literature
| S-EPMC4504790 | biostudies-literature
| S-EPMC6024204 | biostudies-literature
| S-EPMC3188480 | biostudies-literature
| S-EPMC5418643 | biostudies-literature