Ontology highlight
ABSTRACT:
SUBMITTER: Luque RM
PROVIDER: S-EPMC4378269 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Luque Raúl M RM Ibáñez-Costa Alejandro A Neto Leonardo Vieira LV Taboada Giselle F GF Hormaechea-Agulla Daniel D Kasuki Leandro L Venegas-Moreno Eva E Moreno-Carazo Alberto A Gálvez María Ángeles MÁ Soto-Moreno Alfonso A Kineman Rhonda D RD Culler Michael D MD Gahete Manuel D MD Gadelha Mônica R MR Castaño Justo P JP
Cancer letters 20150128 2
The GH/IGF1 response of somatotropinomas to somatostatin analogues (SSA) is associated with their pattern of somatostatin receptor (sst1-sst5) expression. Recently, we demonstrated that expression of a truncated sst5-variant (sst5TMD4) can influence the secretory response of somatotropinomas to SSA-therapy; however, its potential relationship with aggressive features (e.g. invasion/proliferation) is still unknown. Here, we show that sst5TMD4 is present in 50% of non-functioning pituitary-adenoma ...[more]