Ontology highlight
ABSTRACT:
SUBMITTER: Petit D
PROVIDER: S-EPMC4379398 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Petit Daniel D Teppa Elin E Mir Anne-Marie AM Vicogne Dorothée D Thisse Christine C Thisse Bernard B Filloux Cyril C Harduin-Lepers Anne A
Molecular biology and evolution 20141221 4
Sialyltransferases are responsible for the synthesis of a diverse range of sialoglycoconjugates predicted to be pivotal to deuterostomes' evolution. In this work, we reconstructed the evolutionary history of the metazoan α2,3-sialyltransferases family (ST3Gal), a subset of sialyltransferases encompassing six subfamilies (ST3Gal I-ST3Gal VI) functionally characterized in mammals. Exploration of genomic and expressed sequence tag databases and search of conserved sialylmotifs led to the identifica ...[more]