Ontology highlight
ABSTRACT:
SUBMITTER: Nam HJ
PROVIDER: S-EPMC4379487 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Nam Hyun-Ja HJ van Deursen Jan M JM
Nature cell biology 20140428 6
Cyclins B1 and B2 are frequently elevated in human cancers and are associated with tumour aggressiveness and poor clinical outcome; however, whether and how B-type cyclins drive tumorigenesis is unknown. Here we show that cyclin B1 and B2 transgenic mice are highly prone to tumours, including tumour types where B-type cyclins serve as prognosticators. Cyclins B1 and B2 both induce aneuploidy when overexpressed but through distinct mechanisms, with cyclin B1 inhibiting separase activation, leadin ...[more]