Ontology highlight
ABSTRACT:
SUBMITTER: Lowery JW
PROVIDER: S-EPMC4379725 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Lowery Jonathan W JW Intini Giuseppe G Gamer Laura L Lotinun Sutada S Salazar Valerie S VS Ote Satoshi S Cox Karen K Baron Roland R Rosen Vicki V
Journal of cell science 20150206 7
Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGFβ signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors ACVR2A and ACVR2B bind BMPs and activins but the type 2 receptor BMPR2 only binds BMPs, suggesting that type 2 receptor utilization might play a role in mediating the interaction of these pathways. We tested this hypothesis in the mouse skeleton, where bone mass is reciproc ...[more]