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Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora.

ABSTRACT: Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 ?M.

SUBMITTER: Fu P

PROVIDER: S-EPMC4380196 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora.

Fu Peng P MacMillan John B JB

Journal of natural products 20150113 3

Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 μM. ...[more]

PMID: 25584783

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