Ontology highlight
ABSTRACT:
SUBMITTER: Chang EK
PROVIDER: S-EPMC4380364 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Chang Elizabeth K EK Eckert Mark A MA Ali M Monsur MM Riazifar Hamidreza H Pone Egest J EJ Liu Linan L Zhao Weian W
PloS one 20150331 3
Multivalent interactions occur frequently in nature, where they mediate high-affinity interactions between cells, proteins, or molecules. Here, we report on a method to generate multivalent aptamers (Multi-Aptamers) that target L-selectin function using rolling circle amplification (RCA). We find that the L-selectin Multi-Aptamers have increased affinity compared to the monovalent aptamer, are specific to L-selectin, and are capable of inhibiting interactions with endogenous ligands. In addition ...[more]