Ontology highlight
ABSTRACT:
SUBMITTER: Kleino I
PROVIDER: S-EPMC4380453 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kleino Iivari I Järviluoma Annika A Hepojoki Jussi J Huovila Ari Pekka AP Saksela Kalle K
PloS one 20150331 3
A disintegrin and metalloproteinases (ADAMs) constitute a protein family essential for extracellular signaling and regulation of cell adhesion. Catalytic activity of ADAMs and their predicted potential for Src-homology 3 (SH3) domain binding show a strong correlation. Here we present a comprehensive characterization of SH3 binding capacity and preferences of the catalytically active ADAMs 8, 9, 10, 12, 15, 17, and 19. Our results revealed several novel interactions, and also confirmed many previ ...[more]