Ontology highlight
ABSTRACT:
SUBMITTER: Gemperle J
PROVIDER: S-EPMC5556061 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20170814 1
CAS is a docking protein downstream of the proto-oncogene Src with a role in invasion and metastasis of cancer cells. The CAS SH3 domain is indispensable for CAS-mediated signaling, but structural aspects of CAS SH3 ligand binding and regulation are not well understood. Here, we identified the consensus CAS SH3 binding motif and structurally characterized the CAS SH3 domain in complex with ligand. We revealed the requirement for an uncommon centrally localized lysine residue at position +2 of CA ...[more]