Ontology highlight
ABSTRACT:
SUBMITTER: Mueller S
PROVIDER: S-EPMC4380929 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Mueller Stephanie S Huard Jérémy J Waldow Katharina K Huang Xiaoyun X D'Alessandro Lorenza A LA Bohl Sebastian S Börner Kathleen K Grimm Dirk D Klamt Steffen S Klingmüller Ursula U Schilling Marcel M
Molecular systems biology 20150301 3
Liver regeneration is a tightly controlled process mainly achieved by proliferation of usually quiescent hepatocytes. The specific molecular mechanisms ensuring cell division only in response to proliferative signals such as hepatocyte growth factor (HGF) are not fully understood. Here, we combined quantitative time-resolved analysis of primary mouse hepatocyte proliferation at the single cell and at the population level with mathematical modeling. We showed that numerous G1/S transition compone ...[more]