Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC4381282 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Lu Yan Y Dong Hailong H Gao Yandong Y Gong Yuanyuan Y Ren Yingna Y Gu Nan N Zhou Shudi S Xia Nan N Sun Yan-Yan YY Ji Ru-Rong RR Xiong Lize L
The Journal of clinical investigation 20130827 9
Neuropathic pain is characterized by mechanical allodynia induced by low-threshold myelinated Aβ-fiber activation. The original gate theory of pain proposes that inhibitory interneurons in the lamina II of the spinal dorsal horn (DH) act as "gate control" units for preventing the interaction between innocuous and nociceptive signals. However, our understanding of the neuronal circuits underlying pain signaling and modulation in the spinal DH is incomplete. Using a rat model, we have shown that t ...[more]