Ontology highlight
ABSTRACT:
SUBMITTER: Boyle KA
PROVIDER: S-EPMC6635381 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Cell reports 20190701 2
Chronic pain presents a major unmet clinical problem. The development of more effective treatments is hindered by our limited understanding of the neuronal circuits underlying sensory perception. Here, we show that parvalbumin (PV)-expressing dorsal horn interneurons modulate the passage of sensory information conveyed by low-threshold mechanoreceptors (LTMRs) directly via presynaptic inhibition and also gate the polysynaptic relay of LTMR input to pain circuits by inhibiting lamina II excitator ...[more]