Ontology highlight
ABSTRACT:
SUBMITTER: Wohlert D
PROVIDER: S-EPMC4381880 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
eLife 20141126
Sodium/proton antiporters maintain intracellular pH and sodium levels. Detailed structures of antiporters with bound substrate ions are essential for understanding how they work. We have resolved the substrate ion in the dimeric, electroneutral sodium/proton antiporter PaNhaP from Pyrococcus abyssi at 3.2 Å, and have determined its structure in two different conformations at pH 8 and pH 4. The ion is coordinated by three acidic sidechains, a water molecule, a serine and a main-chain carbonyl in ...[more]