Ontology highlight
ABSTRACT:
SUBMITTER: Pershing NL
PROVIDER: S-EPMC4382256 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Pershing Nicole L K NL Lampson Benjamin L BL Belsky Jason A JA Kaltenbrun Erin E MacAlpine David M DM Counter Christopher M CM
The Journal of clinical investigation 20141201 1
The KRAS gene is commonly mutated in human cancers, rendering the encoded small GTPase constitutively active and oncogenic. This gene has the unusual feature of being enriched for rare codons, which limit protein expression. Here, to determine the effect of the rare codon bias of the KRAS gene on de novo tumorigenesis, we introduced synonymous mutations that converted rare codons into common codons in exon 3 of the Kras gene in mice. Compared with control animals, mice with at least 1 copy of th ...[more]