Ontology highlight
ABSTRACT:
SUBMITTER: Kruspig B
PROVIDER: S-EPMC6881183 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Kruspig Björn B Monteverde Tiziana T Neidler Sarah S Hock Andreas A Kerr Emma E Nixon Colin C Clark William W Hedley Ann A Laing Sarah S Coffelt Seth B SB Le Quesne John J Dick Craig C Vousden Karen H KH Martins Carla P CP Murphy Daniel J DJ
Science translational medicine 20180601 446
KRAS is the most frequently mutated driver oncogene in human adenocarcinoma of the lung. There are presently no clinically proven strategies for treatment of KRAS-driven lung cancer. Activating mutations in KRAS are thought to confer independence from upstream signaling; however, recent data suggest that this independence may not be absolute. We show that initiation and progression of KRAS-driven lung tumors require input from ERBB family receptor tyrosine kinases (RTKs): Multiple ERBB RTKs are ...[more]