Ontology highlight
ABSTRACT:
SUBMITTER: Xiong J
PROVIDER: S-EPMC4382653 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Xiong J J Bian J J Wang L L Zhou J-Y JY Wang Y Y Zhao Y Y Wu L-L LL Hu J-J JJ Li B B Chen S-J SJ Yan C C Zhao W-L WL
Blood cancer journal 20150313
Cancer cells have distinct metabolomic profile. Metabolic enzymes regulate key oncogenic signaling pathways and have an essential role on tumor progression. Here, serum metabolomic analysis was performed in 45 patients with T-cell lymphoma (TCL) and 50 healthy volunteers. The results showed that dysregulation of choline metabolism occurred in TCL and was related to tumor cell overexpression of choline kinase-α (Chokα). In T-lymphoma cells, pharmacological and molecular silencing of Chokα signifi ...[more]