Ontology highlight
ABSTRACT:
SUBMITTER: Yelshanskaya MV
PROVIDER: S-EPMC4383034 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Yelshanskaya Maria V MV Li Minfen M Sobolevsky Alexander I AI
Science (New York, N.Y.) 20140807 6200
Ionotropic glutamate receptors (iGluRs) mediate most excitatory neurotransmission in the central nervous system and function by opening their ion channel in response to binding of agonist glutamate. Here, we report a structure of a homotetrameric rat GluA2 receptor in complex with partial agonist (S)-5-nitrowillardiine. Comparison of this structure with the closed-state structure in complex with competitive antagonist ZK 200775 suggests conformational changes that occur during iGluR gating. Guid ...[more]