Ontology highlight
ABSTRACT:
SUBMITTER: Walker CS
PROVIDER: S-EPMC1502309 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Walker Craig S CS Francis Michael M MM Brockie Penelope J PJ Madsen David M DM Zheng Yi Y Maricq Andres V AV
Proceedings of the National Academy of Sciences of the United States of America 20060703 28
The neurotransmitter glutamate mediates excitatory synaptic transmission by activating ionotropic glutamate receptors (iGluRs). In Caenorhabditis elegans, the GLR-1 receptor subunit is required for glutamate-gated current in a subset of interneurons that control avoidance behaviors. Current mediated by GLR-1-containing iGluRs depends on SOL-1, a transmembrane CUB-domain protein that immunoprecipitates with GLR-1. We have found that reconstitution of glutamate-gated current in heterologous cells ...[more]