Ontology highlight
ABSTRACT:
SUBMITTER: Woo SR
PROVIDER: S-EPMC4384884 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Woo Seng-Ryong SR Fuertes Mercedes B MB Corrales Leticia L Spranger Stefani S Furdyna Michael J MJ Leung Michael Y K MY Duggan Ryan R Wang Ying Y Barber Glen N GN Fitzgerald Katherine A KA Alegre Maria-Luisa ML Gajewski Thomas F TF
Immunity 20141105 5
Spontaneous T cell responses against tumors occur frequently and have prognostic value in patients. The mechanism of innate immune sensing of immunogenic tumors leading to adaptive T cell responses remains undefined, although type I interferons (IFNs) are implicated in this process. We found that spontaneous CD8(+) T cell priming against tumors was defective in mice lacking stimulator of interferon genes complex (STING), but not other innate signaling pathways, suggesting involvement of a cytoso ...[more]