Structural organization of the dynein-dynactin complex bound to microtubules.
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ABSTRACT:
SUBMITTER: Chowdhury S
PROVIDER: S-EPMC4385409 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Structural organization of the dynein-dynactin complex bound to microtubules.
Chowdhury Saikat S Ketcham Stephanie A SA Schroer Trina A TA Lander Gabriel C GC
Nature structural & molecular biology 20150309 4
Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the organization of native bovine dynein, dynactin and the dynein-dynactin-microtubule quaternary complex. In the microtubule-bound complex, the dynein motor domains are positioned for processive unidirectional movement, and the cargo-binding domains of both dynein and dynactin are accessible. ...[more]
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