Ontology highlight
ABSTRACT:
SUBMITTER: Ochiana SO
PROVIDER: S-EPMC4385514 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Ochiana Stefan O SO Bland Nicholas D ND Settimo Luca L Campbell Robert K RK Pollastri Michael P MP
Chemical biology & drug design 20141118 5
Cyclic nucleotide phosphodiesterases (PDEs) have been identified as important enzyme targets for drug development in both humans and Trypanosoma brucei, the causative agent of human African trypanosomiasis. With this in mind, we recently reported the profiling of a range of human phosphodiesterase inhibitors, showing that human PDE4 inhibitors tend to display the best potency against the trypanosomal phosphodiesterase TbrPDEB1. Among these was GSK-256066, a potent inhibitor of human PDE4 and a w ...[more]