Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC4385864 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Liu Lanxin L Kimball Sarah S Liu Hui H Holowatyj Andreana A Yang Zeng-Quan ZQ
Oncotarget 20150201 4
Histone lysine methyltransferases (HMTs), a large class of enzymes that catalyze site-specific methylation of lysine residues on histones and other proteins, play critical roles in controlling transcription, chromatin architecture, and cellular differentiation. However, the genomic landscape and clinical significance of HMTs in breast cancer remain poorly characterized. Here, we conducted a meta-analysis of approximately 50 HMTs in breast cancer and identified associations among recurrent copy n ...[more]