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Chemical probes of histone lysine methyltransferases.


ABSTRACT: Growing evidence suggests that histone methyltransferases (HMTs, also known as protein methyltransferases (PMTs)) play an important role in diverse biological processes and human diseases by regulating gene expression and the chromatin state. Therefore, HMTs have been increasingly recognized by the biomedical community as a class of potential therapeutic targets. High quality chemical probes of HMTs, as tools for deciphering their physiological functions and roles in human diseases and testing therapeutic hypotheses, are critical for advancing this promising field. In this review, we focus on the discovery, characterization, and biological applications of chemical probes for HMTs.

SUBMITTER: Kaniskan HU 

PROVIDER: S-EPMC4301070 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Chemical probes of histone lysine methyltransferases.

Kaniskan H Ümit HÜ   Jin Jian J  

ACS chemical biology 20141125 1


Growing evidence suggests that histone methyltransferases (HMTs, also known as protein methyltransferases (PMTs)) play an important role in diverse biological processes and human diseases by regulating gene expression and the chromatin state. Therefore, HMTs have been increasingly recognized by the biomedical community as a class of potential therapeutic targets. High quality chemical probes of HMTs, as tools for deciphering their physiological functions and roles in human diseases and testing t  ...[more]

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