Dataset Information
Investigation on the IL-18 -607A/C and -137C/G on the susceptibility of ischemic stroke.
Ontology highlight
ABSTRACT: Objective
We conducted a case-control study with 322 cases and 322 controls to assess the role of the two common SNPs in the promoter of IL-18 gene.Methods
Polymerase chain reaction restriction fragment length of polymorphism (PCR-RFLP) was taken to genotype -607A/C and -137C/G in the promoter of the IL-18 gene.Results
By comparing cases and control subjects, we found that IS cases were more likely to have higher BMI, higher proportion of hypertension, and have higher proportion of smokers and drinkers. We found that IL-18 -607CC genotype (OR=1.70, 95% CI=1.03-2.81) and C allele (OR=1.26, 95% CI=1.01-1.58) were significantly more frequent in IS patients when compared with AA genotype. We did not find significant association between IL-18 -607A/C gene polymorphism and BMI, hypertension, smoking and drinking on the risk of IS.Conclusion
Our study suggests that polymorphisms in IL-18 -607A/C can influence the development of IS, and this gene polymorphism is associated with risk of IS in a Chinese population.
SUBMITTER: Shi JH
PROVIDER: S-EPMC4386186 | biostudies-literature | 2015 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
Investigation on the IL-18 -607A/C and -137C/G on the susceptibility of ischemic stroke.
Pakistan journal of medical sciences 20150101 1
<h4>Objective</h4>We conducted a case-control study with 322 cases and 322 controls to assess the role of the two common SNPs in the promoter of IL-18 gene.<h4>Methods</h4>Polymerase chain reaction restriction fragment length of polymorphism (PCR-RFLP) was taken to genotype -607A/C and -137C/G in the promoter of the IL-18 gene.<h4>Results</h4>By comparing cases and control subjects, we found that IS cases were more likely to have higher BMI, higher proportion of hypertension, and have higher pro ...[more]
