Ontology highlight
ABSTRACT:
SUBMITTER: Clarke HF
PROVIDER: S-EPMC4386364 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Clarke Hannah F HF Horst Nicole K NK Roberts Angela C AC
Proceedings of the National Academy of Sciences of the United States of America 20150316 13
Dysregulation of the orbitofrontal and ventrolateral prefrontal cortices is implicated in anxiety and mood disorders, but the specific contributions of each region are unknown, including how they gate the impact of threat on decision making. To address this, the effects of GABAergic inactivation of these regions were studied in marmoset monkeys performing an instrumental approach-avoidance decision-making task that is sensitive to changes in anxiety. Inactivation of either region induced a negat ...[more]