Ontology highlight
ABSTRACT:
SUBMITTER: Gao P
PROVIDER: S-EPMC4386733 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Gao Pu P Ascano Manuel M Zillinger Thomas T Wang Weiyi W Dai Peihong P Serganov Artem A AA Gaffney Barbara L BL Shuman Stewart S Jones Roger A RA Deng Liang L Hartmann Gunther G Barchet Winfried W Tuschl Thomas T Patel Dinshaw J DJ
Cell 20130801 4
Binding of dsDNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) triggers formation of the metazoan second messenger c[G(2',5')pA(3',5')p], which binds the signaling protein STING with subsequent activation of the interferon (IFN) pathway. We show that human hSTING(H232) adopts a "closed" conformation upon binding c[G(2',5')pA(3',5')p] and its linkage isomer c[G(2',5')pA(2',5')p], as does mouse mSting(R231) on binding c[G(2',5')pA(3',5')p], c[G(3',5')pA(3',5')p] and the antiviral agent DMXAA, leading ...[more]