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Noble gases as cardioprotectants - translatability and mechanism.

ABSTRACT: Several noble gases, although classified as inert substances, exert a tissue-protective effect in different experimental models when applied before organ ischaemia as an early or late preconditioning stimulus, after ischaemia as a post-conditioning stimulus or when given in combination before, during and/or after ischaemia. A wide range of organs can be protected by these inert substances, in particular cardiac and neuronal tissue. In this review we summarize the data on noble gas-induced cardioprotection, focusing on the underlying protective mechanisms. We will also look at translatability of experimental data to the clinical situation.

SUBMITTER: Smit KF

PROVIDER: S-EPMC4386981 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Noble gases as cardioprotectants - translatability and mechanism.

Smit Kirsten F KF Weber Nina C NC Hollmann Markus W MW Preckel Benedikt B

British journal of pharmacology 20150112 8

Several noble gases, although classified as inert substances, exert a tissue-protective effect in different experimental models when applied before organ ischaemia as an early or late preconditioning stimulus, after ischaemia as a post-conditioning stimulus or when given in combination before, during and/or after ischaemia. A wide range of organs can be protected by these inert substances, in particular cardiac and neuronal tissue. In this review we summarize the data on noble gas-induced cardio ...[more]

PMID: 25363501

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