Browse
Submit Data
Databases
API
Help

Dataset Information

25 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Noble gases as cardioprotectants - translatability and mechanism.

ABSTRACT: Several noble gases, although classified as inert substances, exert a tissue-protective effect in different experimental models when applied before organ ischaemia as an early or late preconditioning stimulus, after ischaemia as a post-conditioning stimulus or when given in combination before, during and/or after ischaemia. A wide range of organs can be protected by these inert substances, in particular cardiac and neuronal tissue. In this review we summarize the data on noble gas-induced cardioprotection, focusing on the underlying protective mechanisms. We will also look at translatability of experimental data to the clinical situation.

SUBMITTER: Smit KF

PROVIDER: S-EPMC4386981 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Noble gases as cardioprotectants - translatability and mechanism.

Smit Kirsten F KF Weber Nina C NC Hollmann Markus W MW Preckel Benedikt B

British journal of pharmacology 20150112 8

Several noble gases, although classified as inert substances, exert a tissue-protective effect in different experimental models when applied before organ ischaemia as an early or late preconditioning stimulus, after ischaemia as a post-conditioning stimulus or when given in combination before, during and/or after ischaemia. A wide range of organs can be protected by these inert substances, in particular cardiac and neuronal tissue. In this review we summarize the data on noble gas-induced cardio ...[more]

PMID: 25363501

Similar Datasets

Indigenous noble gases in the Moon's interior.

Project description:The origin of volatiles in the Moon's interior is debated. Scenarios range from inheritance through a Moon-forming disk or "synestia" to late accretion by meteorites or comets. Noble gases are excellent tracers of volatile origins. We report analyses of all noble gases in paired, unbrecciated lunar mare basalts and show that magmatic glasses therein contain indigenous noble gases including solar-type He and Ne. Assimilation of solar wind (SW)-bearing regolith by the basaltic melt or SW implantation into the basalts is excluded on the basis of the petrological context of the samples, as well as the lack of SW and "excess 40Ar" in the magmatic minerals. The absence of chondritic primordial He and Ne signatures excludes exogenous contamination. We thus conclude that the Moon inherited indigenous noble gases from Earth's mantle by the Moon-forming impact and propose storage in the incompatible element-enriched ("KREEP") reservoir.

| S-EPMC9365290 | biostudies-literature

Primordial heavy noble gases in the pristine Paris carbonaceous chondrite.

Project description:The Paris carbonaceous chondrite represents the most pristine carbonaceous chondrite, providing a unique opportunity to investigate the composition of early solar system materials prior to the onset of significant aqueous alteration. A dual origin (namely from the inner and outer solar system) has been demonstrated for water in the Paris meteorite parent body (Piani et al. 2018). Here, we aim to evaluate the contribution of outer solar system (cometary-like) water ice to the inner solar system water ice using Xe isotopes. We report Ar, Kr, and high-precision Xe isotopic measurements within bulk CM 2.9 and CM 2.7 fragments, as well as Ne, Ar, Kr, and Xe isotope compositions of the insoluble organic matter (IOM). Noble gas signatures are similar to chondritic phase Q with no evidence for a cometary-like Xe component. Small excesses in the heavy Xe isotopes relative to phase Q within bulk samples are attributed to contributions from presolar materials. CM 2.7 fragments have lower Ar/Xe relative to more pristine CM 2.9 fragments, with no systematic difference in Xe contents. We conclude that Kr and Xe were little affected by aqueous alteration, in agreement with (1) minor degrees of alteration and (2) no significant differences in the chemical signature of organic matter in CM 2.7 and CM 2.9 areas (Vinogradoff et al. 2017). Xenon contents in the IOM are larger than previously published data of Xe in chondritic IOM, in line with the Xe component in Paris being pristine and preserved from Xe loss during aqueous alteration/thermal metamorphism.

| S-EPMC6378587 | biostudies-literature

Noble gases confirm plume-related mantle degassing beneath Southern Africa.

Project description:Southern Africa is characterised by unusually elevated topography and abnormal heat flow. This can be explained by thermal perturbation of the mantle, but the origin of this is unclear. Geophysics has not detected a thermal anomaly in the upper mantle and there is no geochemical evidence of an asthenosphere mantle contribution to the Cenozoic volcanic record of the region. Here we show that natural CO2 seeps along the Ntlakwe-Bongwan fault within KwaZulu-Natal, South Africa, have C-He isotope systematics that support an origin from degassing mantle melts. Neon isotopes indicate that the melts originate from a deep mantle source that is similar to the mantle plume beneath Réunion, rather than the convecting upper mantle or sub-continental lithosphere. This confirms the existence of the Quathlamba mantle plume and importantly provides the first evidence in support of upwelling deep mantle beneath Southern Africa, helping to explain the regions elevation and abnormal heat flow.

| S-EPMC6831580 | biostudies-literature

Unsupported Donor-Acceptor Complexes of Noble Gases with Group 13 Elements.

Project description:Unsupported donor-acceptor complexes of noble gases (Ng) with group 13 elements have been theoretically studied using density functional theory. Calculations reveal that heavier noble gases form thermodynamically stable compounds. The present study reveals that no rigid framework is necessary to stabilize the donor-acceptor complexes. Rather, prepyramidalization at the Lewis acid center may be an interesting alternative to stabilize these complexes. Detailed bonding analyses reveal the formation of two-center-two-electron dative bonding, where Ng atoms act as a donor.

| S-EPMC8015094 | biostudies-literature

Leading Interaction Components in the Structure and Reactivity of Noble Gases Compounds.

Project description:The nature, strength, range and role of the bonds in adducts of noble gas atoms with both neutral and ionic partners have been investigated by exploiting a fine-tuned integrated phenomenological-theoretical approach. The identification of the leading interaction components in the noble gases adducts and their modeling allows the encompassing of the transitions from pure noncovalent to covalent bound aggregates and to rationalize the anomalous behavior (deviations from noncovalent type interaction) pointed out in peculiar cases. Selected adducts affected by a weak chemical bond, as those promoting the formation of the intermolecular halogen bond, are also properly rationalized. The behavior of noble gas atoms excited in their long-life metastable states, showing a strongly enhanced reactivity, has been also enclosed in the present investigation.

| S-EPMC7287633 | biostudies-literature

Author Correction: Noble gases confirm plume-related mantle degassing beneath Southern Africa.

Project description: Not available

| S-EPMC10449882 | biostudies-literature

Remote conditioning the heart overview: translatability and mechanism.

Project description:Conditioning the heart to resist predictable and unpredictable ischaemia-reperfusion (IR) injury is one of the fastest growing areas of bench to bedside research within cardiology. Basic science has provided important insights into signalling pathways and protective mechanisms in the heart, and a growing number of clinical studies have, with important exceptions, shown the potential applicability and beneficial effect of various mechanical conditioning strategies achieved by intermittent short-lasting-induced ischaemia of the heart itself or a remote tissue. Remote ischaemic conditioning (RIC) in particular has been utilized in a number of clinical settings with promising results. However, while many novel 'downstream' mechanisms of RIC have been discovered, translation to pharmacological conditioning has not yet been convincingly demonstrated in clinical studies. One explanation for this apparent failure may be that most pharmacological approaches mimic a single instrument in a complex orchestra activated by mechanical conditioning. Recent studies, however, provide important insights into upstream events occurring in RIC, which may allow for development of drugs activating more complex systems of biological organ protection. With this review, we will systematically examine the first generation of pharmacological cardioprotection studies and then provide a summary of the recent discoveries in basic science that could illuminate the path towards more advanced approaches in the next generation of pharmacological agents that may work by reproducing the diverse effects of RIC, thereby providing protection against IR injury.

| S-EPMC4386974 | biostudies-literature

Exploring the Effects on Lipid Bilayer Induced by Noble Gases via Molecular Dynamics Simulations.

Project description:Noble gases seem to have no significant effect on the anesthetic targets due to their simple, spherical shape. However, xenon has strong narcotic efficacy and can be used clinically, while other noble gases cannot. The mechanism remains unclear. Here, we performed molecular dynamics simulations on phospholipid bilayers with four kinds of noble gases to elucidate the difference of their effects on the membrane. Our results showed that the sequence of effects on membrane exerted by noble gases from weak to strong was Ne, Ar, Kr and Xe, the same order as their relative narcotic potencies as well as their lipid/water partition percentages. Compared with the other three kinds of noble gases, more xenon molecules were distributed between the lipid tails and headgroups, resulting in membrane's lateral expansion and lipid tail disorder. It may contribute to xenon's strong anesthetic potency. The results are well consistent with the membrane mediated mechanism of general anesthesia.

| S-EPMC4658558 | biostudies-literature

Primitive noble gases sampled from ocean island basalts cannot be from the Earth's core.

Project description:Noble gas isotopes in plumes require a source of primitive volatiles largely isolated in the Earth for 4.5 Gyrs. Among the proposed reservoirs, the core is gaining interest in the absence of robust geochemical and geophysical evidence for a mantle source. This is supported by partitioning data showing that sufficient He and Ne could have been incorporated into the core to source plumes today. Here we perform ab initio calculations on the partitioning of He, Ne, Ar, Kr and Xe between liquid iron and silicate melt under core forming conditions. For He our results are consistent with previous studies allowing for substantial amounts of He in the core. In contrast, the partition coefficient for Ne is three orders of magnitude lower than He. This very low partition coefficient would result in a 3He/22Ne ratio of ~103 in the core, far higher than observed in ocean island basalts (OIBs). We conclude that the core is not the source of noble gases in OIBs.

| S-EPMC9247082 | biostudies-literature

Opacity and conductivity measurements in noble gases at conditions of planetary and stellar interiors.

Project description:The noble gases are elements of broad importance across science and technology and are primary constituents of planetary and stellar atmospheres, where they segregate into droplets or layers that affect the thermal, chemical, and structural evolution of their host body. We have measured the optical properties of noble gases at relevant high pressures and temperatures in the laser-heated diamond anvil cell, observing insulator-to-conductor transformations in dense helium, neon, argon, and xenon at 4,000-15,000 K and pressures of 15-52 GPa. The thermal activation and frequency dependence of conduction reveal an optical character dominated by electrons of low mobility, as in an amorphous semiconductor or poor metal, rather than free electrons as is often assumed for such wide band gap insulators at high temperatures. White dwarf stars having helium outer atmospheres cool slower and may have different color than if atmospheric opacity were controlled by free electrons. Helium rain in Jupiter and Saturn becomes conducting at conditions well correlated with its increased solubility in metallic hydrogen, whereas a deep layer of insulating neon may inhibit core erosion in Saturn.

| S-EPMC4491786 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data