Ontology highlight
ABSTRACT:
SUBMITTER: Cheng LE
PROVIDER: S-EPMC4387286 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20150316 4
Vertebrate immunity has evolved a modular architecture in response to perturbations. Allergic inflammation represents such a module, with signature features of antigen-specific IgE and tissue eosinophilia, although the cellular and molecular circuitry coupling these responses remains unclear. Here, we use genetic and imaging approaches in models of IgE-dependent eosinophilic dermatitis to demonstrate a requisite role for basophils. After antigenic inflammation, basophils initiate transmigration ...[more]