Ontology highlight
ABSTRACT:
SUBMITTER: Hatzi K
PROVIDER: S-EPMC4387288 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Hatzi Katerina K Nance J Philip JP Kroenke Mark A MA Bothwell Marcella M Haddad Elias K EK Melnick Ari A Crotty Shane S
The Journal of experimental medicine 20150330 4
Follicular helper T cells (Tfh cells) are required for T cell help to B cells, and BCL6 is the defining transcription factor of Tfh cells. However, the functions of BCL6 in Tfh cells have largely remained unclear. Here we defined the BCL6 cistrome in primary human germinal center Tfh cells to assess mechanisms of BCL6 regulation of CD4 T cells, comparing and contrasting BCL6 function in T and B cells. BCL6 primarily acts as a repressor in Tfh cells, and BCL6 binding was associated with control o ...[more]