Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC6303346 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Li Fengyin F Zeng Zhouhao Z Xing Shaojun S Gullicksrud Jodi A JA Shan Qiang Q Choi Jinyong J Badovinac Vladimir P VP Crotty Shane S Peng Weiqun W Xue Hai-Hui HH
Nature communications 20181221 1
Ezh2 is an histone methyltransferase (HMT) that catalyzes H3K27me3 and functions in T<sub>H</sub>1, T<sub>H</sub>2, and Treg cells primarily via HMT activity. Here we show that Ezh2 ablation impairs T follicular helper (T<sub>FH</sub>) cell differentiation and activation of the T<sub>FH</sub> transcription program. In T<sub>FH</sub> cells, most Ezh2-occupied genomic sites, including the Bcl6 promoter, are associated with H3K27ac rather than H3K27me3. Mechanistically, Ezh2 is recruited by Tcf1 to ...[more]