Ontology highlight
ABSTRACT:
SUBMITTER: Chen T
PROVIDER: S-EPMC4387555 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Chen Tian T Xiang Jian-Feng JF Zhu Shanshan S Chen Siye S Yin Qing-Fei QF Zhang Xiao-Ou XO Zhang Jun J Feng Hua H Dong Rui R Li Xue-Jun XJ Yang Li L Chen Ling-Ling LL
Cell research 20150224 4
Adenosine deaminases acting on RNA (ADARs) are involved in adenosine-to-inosine RNA editing and are implicated in development and diseases. Here we observed that ADAR1 deficiency in human embryonic stem cells (hESCs) significantly affected hESC differentiation and neural induction with widespread changes in mRNA and miRNA expression, including upregulation of self-renewal-related miRNAs, such as miR302s. Global editing analyses revealed that ADAR1 editing activity contributes little to the alter ...[more]