Ontology highlight
ABSTRACT:
SUBMITTER: Mank N
PROVIDER: S-EPMC4388182 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Mank Nicholas N Arnette Amy A Klapper Vince V Offermann Lesa L Chruszcz Maksymilian M
Acta crystallographica. Section F, Structural biology communications 20150320 Pt 4
Dihydrodipicolinate synthase (DapA) catalyzes the first committed step of the diaminopimelate biosynthetic pathway of lysine. It has been shown to be an essential enzyme in many bacteria and has been the subject of research to generate novel antibiotics. However, this pathway is present in both pathogenic and commensal bacteria, and antibiotics targeting DapA may interfere with normal gut colonization. Bacteroides thetaiotaomicron is a Gram-negative commensal bacterium that makes up a large prop ...[more]