Ontology highlight
ABSTRACT:
SUBMITTER: Hu YH
PROVIDER: S-EPMC4388611 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Hu Yun-Hong YH Zhang Yu Y Jiang Li-Qun LQ Wang Shuai S Lei Cao-Qi CQ Sun Ming-Shun MS Shu Hong-Bing HB Liu Yu Y
EMBO reports 20150303 4
Toll-like receptors (TLRs) are pattern recognition receptors that sense a variety of pathogens, initiate innate immune responses, and direct adaptive immunity. All TLRs except TLR3 recruit the adaptor MyD88 to ultimately elicit inflammatory gene expression, whereas TLR3 and internalized TLR4 use TIR-domain-containing adaptor TRIF for the induction of type I interferon and inflammatory cytokines. Here, we identify the WD repeat and FYVE-domain-containing protein WDFY1 as a crucial adaptor protein ...[more]