Ontology highlight
ABSTRACT:
SUBMITTER: Zang R
PROVIDER: S-EPMC7232131 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Zang Ru R Lian Huan H Zhong Xuan X Yang Qing Q Shu Hong-Bing HB
Journal of molecular cell biology 20200501 4
Toll-like receptor 3 (TLR3)-mediated signaling is important for host defense against RNA virus. Upon viral RNA stimulation, toll and interleukin-1 receptor domain-containing adaptor inducing IFN-β (TRIF) is recruited to TLR3 and then undergoes oligomerization, which is required for the recruitment of downstream molecules to transmit signals. Here, we identified zinc finger CCHC-type containing 3 (ZCCHC3) as a positive regulator of TLR3-mediated signaling. Overexpression of ZCCHC3 promoted transc ...[more]