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BTNL2 gene polymorphism and sarcoidosis susceptibility: a meta-analysis.


ABSTRACT: Butyrophilin-like 2 (BTNL2) rs2076530 gene polymorphism has been implicated in susceptibility to sarcoidosis. However, results from previous studies are not consistent. To assess the association of BTNL2 polymorphism and sarcoidosis susceptibility, a meta-analysis was performed.PubMed, Embase were searched for eligible case-control studies. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.Ten studies involving a total of 3303 cases and 2514 controls were included in this meta-analysis. Combined data indicated that BTNL2 rs2076530 polymorphism was associated with sarcoidosis susceptibility in allelic model (A vs. G, OR = 1.59, 95%CI: 1.47-1.72), dominant model (AA + AG vs. GG, OR = 2.10, 95%CI: 1.67-2.65), and recessive model (AA vs. AG + GG, OR = 1.93, 95%CI: 1.49-2.50).This meta-analysis indicates that BTNL2 rs2076530 polymorphism contributes to the risk of sarcoidosis.

SUBMITTER: Lin Y 

PROVIDER: S-EPMC4388687 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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BTNL2 gene polymorphism and sarcoidosis susceptibility: a meta-analysis.

Lin Yihua Y   Wei Jia J   Fan Lili L   Cheng Deyun D  

PloS one 20150407 4


<h4>Background</h4>Butyrophilin-like 2 (BTNL2) rs2076530 gene polymorphism has been implicated in susceptibility to sarcoidosis. However, results from previous studies are not consistent. To assess the association of BTNL2 polymorphism and sarcoidosis susceptibility, a meta-analysis was performed.<h4>Methods</h4>PubMed, Embase were searched for eligible case-control studies. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.<h4>Results</h4>Ten stu  ...[more]

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