Pattern formation by vascular mesenchymal cells.
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ABSTRACT:
SUBMITTER: Garfinkel A
PROVIDER: S-EPMC438961 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Publications
Pattern formation by vascular mesenchymal cells.
Garfinkel Alan A Tintut Yin Y Petrasek Danny D Boström Kristina K Demer Linda L LL
Proceedings of the National Academy of Sciences of the United States of America 20040614 25
In embryogenesis, immature mesenchymal cells aggregate and organize into patterned tissues. Later in life, a pathological recapitulation of this process takes place in atherosclerotic lesions, when vascular mesenchymal cells organize into trabecular bone tissue within the artery wall. Here we show that multipotential adult vascular mesenchymal cells self-organize in vitro into patterns that are predicted by a mathematical model based on molecular morphogens interacting in a reaction-diffusion pr ...[more]
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