Head injury, ?-synuclein genetic variability and Parkinson's disease.
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ABSTRACT:
SUBMITTER: Lee PC
PROVIDER: S-EPMC4390403 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Head injury, α-synuclein genetic variability and Parkinson's disease.
Lee P C PC Bordelon Y Y Bronstein J J Sinsheimer J S JS Farrer M M Ritz B B
European journal of neurology 20141105 5
<h4>Background and purpose</h4>Head injury has been linked to Parkinson's disease (PD) in some but not all studies. Differences in the genetic and environmental susceptibility to PD between populations might be one explanation. The joint effects of head injuries and SNCA genetic variants were investigated.<h4>Methods</h4>From 2001 to 2012, 561 incident idiopathic PD cases and 721 population controls from central California were enrolled. Subjects reported on head injuries throughout their lifeti ...[more]
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