Ontology highlight
ABSTRACT:
SUBMITTER: Ham H
PROVIDER: S-EPMC4390494 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Ham Hyoungjun H Huynh Walter W Schoon Renee A RA Vale Ronald D RD Billadeau Daniel D DD
Journal of immunology (Baltimore, Md. : 1950) 20150311 8
NK cells provide host defense by killing viral-infected and cancerous cells through the secretion of preformed lytic granules. Polarization of the lytic granules toward the target cell is dependent on an intact microtubule (MT) network as well as MT motors. We have recently shown that DOCK8, a gene mutated in a primary immunodeficiency syndrome, is involved in NK cell killing in part through its effects on MT organizing center (MTOC) polarization. In this study, we identified Hook-related protei ...[more]