Ontology highlight
ABSTRACT:
SUBMITTER: Wilton KM
PROVIDER: S-EPMC6317751 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wilton Katelynn M KM Billadeau Daniel D DD
Journal of immunology (Baltimore, Md. : 1950) 20181003 10
NK cells eliminate viral-infected and malignant cells through a highly orchestrated series of cytoskeletal rearrangements, resulting in the release of cytolytic granule contents toward the target cell. Central to this process is the convergence of cytolytic granules to a common point, the microtubule-organizing center (MTOC), before delivery to the synapse. In this study, we show that vasodialator-stimulated phosphoprotein (VASP), an actin regulatory protein, localizes to the cytolytic synapse, ...[more]