Review of health risks of low testosterone and testosterone administration.
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ABSTRACT:
SUBMITTER: Jia H
PROVIDER: S-EPMC4391003 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Review of health risks of low testosterone and testosterone administration.
Jia Huanguang H Sullivan Charles T CT McCoy Sean C SC Yarrow Joshua F JF Morrow Matthew M Borst Stephen E SE
World journal of clinical cases 20150401 4
Hypogonadism is prevalent in older men and testosterone replacement therapy (TRT) for older hypogonadal men is a promising therapy. However, a number of important clinical concerns over TRT safety remain unsolved due to a lack of large-scale randomized clinical trials directly comparing the health risks of untreated hypogonadism vs long-term use of TRT. Meta-analyses of clinical trials of TRT as of 2010 have identified three major adverse events resulting from TRT: polycythemia, an increase in p ...[more]
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